systemic
/sɪˈstɛm.ɪk/
Proposed by a contributor, not yet supported by evidence.
Sense 1
Meaning · English
Embedded within and spread throughout and affecting a whole system, group, body, economy, market, or society.
Adjective
Examples
We can learn from the incidents found it the project database - looking at them and understanding what happened and what might have been done differently. We can see past errors, including systemic issues that required attention at managerial levels.
Usage example from English Wiktionary (CC BY-SA 4.0, retrieved 2026-08-01)
Sources & notes
Adapted from English Wiktionary (CC BY-SA 4.0, retrieved 2026-08-01 via kaikki.org).
Sense 2
Meaning · English
Pertaining to an entire organism.
Adjective
Examples
Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE).
Usage example from English Wiktionary (CC BY-SA 4.0, retrieved 2026-08-01)
Sources & notes
Adapted from English Wiktionary (CC BY-SA 4.0, retrieved 2026-08-01 via kaikki.org).
Common questions
What does “systemic” mean?
Embedded within and spread throughout and affecting a whole system, group, body, economy, market, or society.
Is “systemic” formal or informal?
No register label has been reviewed yet — treat it as neutral and check the usage notes above.