English · Slang Candidate

big C

Proposed by a contributor, not yet supported by evidence.

Meaning · English

cancer.

Where it’s used: Used American English

Examples

You can always count on John Wayne, 57; he never steps out of character. "I kicked the Big C," growled the movie toughie, admitting that it was lung cancer that put him in Los Angeles' Good Samaritan Hospital for surgery last September.

Usage example from English Wiktionary (CC BY-SA 4.0, retrieved 2026-07-30)

Sources & notes

Adapted from English Wiktionary (CC BY-SA 4.0, retrieved 2026-07-30 via kaikki.org).

Common questions

What does “big C” mean?

cancer.

Is “big C” formal or informal?

big C is generally slang.

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